Honors Experience Proposal Example
Honors Experiential Learning Project Proposal Form - Research Complete and submit this proposal in your e-portfolio (for those with iWebfolio portfolios) or email to firstname.lastname@example.org (if you do not have an e-portfolio in iWebfolio).
Full Name: Mahima Venkatesh UC ID #: M04260985 UC Email: email@example.com Phone: 440-334-3924 College: Arts and Sciences Major: Biology Title of Project: Summer Student Research Program at Rainbow Babies and Children’s Hospital Summer: Cdk5 and Cancer Expected Project Start Date: June 11, 2012 Expected Project End Date: August 3, 2012
Project Information 1. Provide a brief overview/abstract of your proposed honors experiential learning project. During the summer of my senior year, I worked as an intern in the Letterio Pediatric Oncology/ Hematology Lab at the Department of Pediatrics at Case Western University. I worked under the Primary Investigator, Dr. Tej Pareek, and I worked with a specific kinase from the cyclin dependent kinase family, Cdk5. Cdk5/p35 complex has been shown to have an important role in the Central Nervous System where it is associated with neuronal migration and synaptic structure and plasticity. Abnormal regulation of Cdk5 is also thought to play a role in certain cancers and neurodegenerative disorders such as Alzheimers and ALS.Cdk5 is an emerging kinase in the study of cancer biology, neuroscience, and immunology, however the lab’s specific interest in the study of Cdk5 focuses on its role in cancer, inflammation, and the immune system. During my 8 weeks there, I learned genomic DNA extraction, protein extraction from tissue and cells, PCR techniques, Western blot, mouse handling and breeding techniques, and general cell culture techniques. I also learned how present a paper in Journal club. I was also able to witness several cell growth assays and Immunofluorescence assays performed by my mentor. As a culminating project, one of my fellow interns and I worked on a project with kinase assays. We completed a project and submitted a invention proposal entitled “Assay Design of a High-Throughput Screening for the Detection of Aberrantly Regulated Kinase Cdk5 in Various Disorders”.
This year I will be part of the Summer Student Research Program at Rainbow Babies and Children’s Hospital. This program was developed to give students interested in careers in biomedical sciences a hands-on experience in research. Selection into the program is based on several criteria, including academic success, particularly in science-related course work, as well as recommendation letters and the student’s personal statement regarding career goals. I will be paired with the Letterio Pediatric Oncology/Hematology Lab under Dr. Tej Pareek. With the help of my lab mentor, I will design and carry out a research project related to the research being done in the lab. Full time hours will generally be 30 to 40 per week, details to be arranged with the lab mentor. Students and mentors will attend meetings once per week at noon. Each student will present a 15-minute seminar at one of these meetings, schedule to be determined once all students have arrived. The start and end dates of the program are somewhat flexible with the approval of the lab mentor. It is anticipated that most students will be here during June, July, and the first half of August. At the end of the program, a one-page summary of the student’s learning experience or work accomplished will be submitted by each student. Payment will be $3,000, payable in two installments (approximately at the end of June and end of July) during the 10-week program. Through this program I will continue my research from last year regarding Cdk5 and cancer. I will learn more hands-on general laboratory research techniques and work more independently with the mouse model experiments. After I gain experience in these areas, I will begin a specific project, which will most likely involve the study of Cdk5 and its role in cancer, inflammation, and the immune system. I will most likely continue my project last year with the Cdk5 kinase assay or I will continue a project already started by my mentor. I will also be an active part of journal club, which will involve independent study outside of the laboratory. I will read peer-reviewed journal articles and other materials to give me more knowledge of the research done at the lab, the techniques of the lab, and the field of oncology. Finally, I will keep a journal and lab notebook outlining what I do everyday. This notebook will also have the materials and methods of different experiments and data from those experiments. 2. Clearly state how each of the following elements will be exhibited in your work (refer to the first two pages of this document with the full description of what is expected in each of these areas).
- Substantial Content and Quality within Research Theme
- Connection to Academic Goals and Theories
- Initiative, Independence and Creativity
- Reflection & Dissemination
- Advisor (list the person’s name, title, and contact information)
- Budget (if applicable)
Payment through the Summer Student Research Program at Rainbow Babies and Children’s Hospital will be $3,000, payable in two installments (approximately at the end of June and end of July) during the 10-week program.